Fluciclovine (18F)

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Scientific Name: Fluciclovine (18F)
Brand Name: Axumin
Company Owner: Not Available
Mechanism Of Action Fluciclovine is transported into the prostate cancer cells via ASCT2 and LAT1 transporters. The activity of LAT1 gets increased in acidic pH, condition that is developed intra-tumorally at certain size. The uptake of fluciclovine presents an androgen-dependent dynamic in hormone sensitive cells.
Description of the Drug: Fluciclovine (18F) is a radiolabelled L-leucine derivative used to image tumors, especially in the prostate.
Protein Data Bank: Not Available
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB13146