Floxuridine
Back to search| Scientific Name: | Floxuridine |
| Brand Name: | Not Available |
| Company Owner: | App pharmaceuticals llc, Bedford laboratories div ben venue laboratories inc, Hospira inc |
| Mechanism Of Action | Floxuridine rapidly undergoes catabolism to form 5-fluorouracil, which is the active component of the drug. 5-Fluorouracil primarily works by interfering with DNA synthesis; however, it may also inhibit the formation of fraudulent RNA via physical incorporation into the RNA. It is also an inhibitor of riboside phophorylase, preventing the utilization of pre-formed uracil in RNA synthesis. Floxuridine can also form 5-fluoro-2′-deoxyuridine-5′-phosphate (FUDR-MP) , which is the monophosphate of floxuridine that inhibits thymidylate synthetase that plays a role in the methylation of deoxyuridylic acid to thymidylic acid during DNA synthesis. FUDR-MP thus interferes with DNA synthesis. |
| Description of the Drug: | Floxuridine is an antimetabolite used as palliative management for liver metastases of gastrointestinal malignancy. |
| Protein Data Bank: | Not Available |
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00322
