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Scientific Name: Ethosuximide
Brand Name: Zarontin
Company Owner: Banner pharmacaps inc, Convenant pharma inc, Parke davis div warner lambert co, Mikart inc, Pharmaceutical assoc inc div beach products, Teva pharmaceuticals usa, Parke davis pharmaceutical research div warner lambert co
Mechanism Of Action Binds to T-type voltage sensitive calcium channels. Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the “low-voltage activated (LVA) ” group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
Description of the Drug: Ethosuximide is an anticonvulsant used to treat petit mal seizures.
Protein Data Bank: Not Available
Source: DrugBank Online – Retrieved 2023-01-23 from