Scientific Name: Estradiol
Brand Name: Activella 1/0.5 28 Day, Activelle, Amabelz 0.5/0.1 28 Day, Angeliq 0.25/0.5 28 Day, Bijuva, Climara, Climara Pro, Combipatch, Divigel, Dotti, Elestrin, Estalis, Estrace, Estradot, Estring, Estrogel, Evamist, Imvexxy 4 Mcg Starter Pack, Lopreeza 1/0.5 28 Day, Lyllana, Menostar, Mimvey, Minivelle, Myfembree, Oesclim, Oriahnn 28 Day Kit, Prefest 30 Day, Vagifem, Vivelle, Yuvafem
Company Owner: Warner chilcott inc, Watson laboratories inc, Bayer healthcare pharmaceuticals inc, Women first healthcare inc, Novartis pharmaceuticals corp, Mylan technologies inc, Ortho mcneil pharmaceutical inc, Parke davis pharmaceutical research div warner lambert co, Azur pharma international ii ltd, Ascend therapeutics inc, Upsher smith laboratories inc, Pharmacia and upjohn co, Kv pharmaceutical co, Bristol myers squibb co, Bristol myers squibb co pharmaceutical research institute, Aai pharma inc, Barr laboratories inc, Heritage pharmaceuticals inc, Mylan pharmaceuticals inc, Usl pharma inc, Duramed pharmaceuticals inc sub barr laboratories inc, Novo nordisk inc, Galen ltd, Graceway pharmaceuticals llc, Jhp pharmaceuticals llc, Pharmaforce inc, Sandoz canada inc, Private formulations inc, Monarch pharmaceuticals inc, Wyeth ayerst laboratories
Mechanism Of Action Estrogen is found in the the breast, uterine, ovarian, skin, prostate, bone, fat, and brain tissues. The main source of estrogen in adult women during the reproductive period of life is the ovarian follicle, which secretes 70 to 500 mcg of estradiol each day. After menopause, however, the majority of endogenous estrogen is produced by transformation of androstenedione (which is secreted by the adrenal cortex) to estrone in the peripheral tissues. Both estrone and its sulphate conjugated form, estrone sulphate, represent the most abundant estrogens found in postmenopausal women.
Description of the Drug: Estradiol is an estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate.
Protein Data Bank:
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00783