Doxorubicin

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Scientific Name: Doxorubicin
Brand Name: Adriamycin, Doxil, Myocet
Company Owner: Ortho biotech products lp, Pharmacia and upjohn co, App pharmaceuticals llc, Bedford laboratories div ben venue laboratories inc, Pharmachemie bv, Teva parenteral medicines inc, Bristol myers squibb co
Mechanism Of Action Doxorubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Doxorubicin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.
Description of the Drug: Doxorubicin is a medication used to treat various cancers and Kaposi’s Sarcoma.
Protein Data Bank:
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00997