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Scientific Name: Dofetilide
Brand Name: Tikosyn
Company Owner: Pfizer pharmaceuticals production corp ltd
Mechanism Of Action The mechanism of action of Dofetilide is a blockade of the cardiac ion channel carrying the rapid component of the delayed rectifier potassium current, IKr. This inhibition of potassium channels results in a prolongation of action potential duration and the effective refractory period of accessory pathways (both anterograde and retrograde conduction in the accessory pathway) .
Description of the Drug: Dofetilide is a class III antiarrhythmic drug used for the maintenance of normal sinus rhythm and cardioversion in cases of atrial fibrillation and atrial flutter.
Protein Data Bank: Not Available
Source: DrugBank Online – Retrieved 2023-01-23 from