Disulfiram
Back to search| Scientific Name: | Disulfiram |
| Brand Name: | Antabuse |
| Company Owner: | Odyssey pharmaceuticals inc, Par pharmaceutical inc, Watson laboratories inc |
| Mechanism Of Action | Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake causing an accumulation of acetaldehyde in the blood producing highly unpleasant symptoms. Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase, which acts in the second step of ethanol utilization. In addition, disulfiram competitively binds and inhibits the peripheral benzodiazepine receptor, which may indicate some value in the treatment of the symptoms of alcohol withdrawal, however this activity has not been extensively studied. |
| Description of the Drug: | Disulfiram is a carbamate derivative used to treat alcohol addiction. |
| Protein Data Bank: | Not Available |
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00822
