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Scientific Name: Dihydroergotamine
Brand Name: Dhe-45, Migranal, Trudhesa
Company Owner: Valeant pharmaceuticals international, Bedford laboratories, Paddock laboratories inc
Mechanism Of Action DHE has several proposed mechanisms which may contribute to its therapeutic efficacy as an abortive therapy in migraines. Firstly, DHE’s s agonist action on 5-hydroxytryptamine (5HT) 1b receptors in the smooth muscle of the cranial vasculature may provide relief via vasoconstriction of the blood vessels which typically become dilated due to the release of CGRP during migraine attacks.
Description of the Drug: Dihydroergotamine is an ergot alkaloid used in the acute treatment of migraine headache and cluster headache.
Protein Data Bank:
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00320