Didanosine

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Scientific Name: Didanosine
Brand Name: Not Available
Company Owner: Aurobindo pharma ltd, Barr laboratories inc, Matrix laboratories ltd, Bristol myers squibb co, Bristol myers squibb co pharmaceutical research institute
Mechanism Of Action Didanosine (ddI) is metabolized intracellularly by a series of cellular enzymes to its active moiety, dideoxyadenosine triphosphate (ddATP) , which inhibits the HIV reverse transcriptase enzyme competitively by competing with natural dATP. It also acts as a chain terminator by its incorporation into viral DNA as the lack of a 3′-OH group in the incorporated nucleoside analogue prevents the formation of the 5′ to 3′ phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated.
Description of the Drug: Didanosine is a reverse transcriptase inhibitor used to treat HIV.
Protein Data Bank:
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00900