Didanosine
Back to search| Scientific Name: | Didanosine |
| Brand Name: | Not Available |
| Company Owner: | Aurobindo pharma ltd, Barr laboratories inc, Matrix laboratories ltd, Bristol myers squibb co, Bristol myers squibb co pharmaceutical research institute |
| Mechanism Of Action | Didanosine (ddI) is metabolized intracellularly by a series of cellular enzymes to its active moiety, dideoxyadenosine triphosphate (ddATP) , which inhibits the HIV reverse transcriptase enzyme competitively by competing with natural dATP. It also acts as a chain terminator by its incorporation into viral DNA as the lack of a 3′-OH group in the incorporated nucleoside analogue prevents the formation of the 5′ to 3′ phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated. |
| Description of the Drug: | Didanosine is a reverse transcriptase inhibitor used to treat HIV. |
| Protein Data Bank: |
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00900
