Daunorubicin

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Scientific Name: Daunorubicin
Brand Name: Cerubidine, Vyxeos
Company Owner: Gilead sciences inc, Bedford laboratories div ben venue laboratories inc, Sanofi aventis us llc, Wyeth ayerst research, App pharmaceuticals llc, Teva parenteral medicines inc
Mechanism Of Action Daunorubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Daunorubicin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.
Description of the Drug: Daunorubicin is an anthracycline aminoglycoside used to induce remission of nonlymphocytic leukemia and acute lymphocytic leukemia.
Protein Data Bank:
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00694