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Scientific Name: Colistimethate
Brand Name: Colobreathe, Coly Mycin M, Xylistin
Company Owner: Not Available
Mechanism Of Action Colistimethate is a surface active agent which penetrates into and disrupts the bacterial cell membrane. Colistimethate is polycationic and has both hydrophobic and lipophilic moieties. It interacts with the bacterial cytoplasmic membrane, changing its permeability. This effect is bactericidal. There is also evidence that polymyxins enter the cell and precipitate cytoplasmic components, primarily ribosomes.
Description of the Drug: Colistimethate is an antibiotic indicated for treatment of infections caused by susceptible strains of certain gram-negative bacilli. It is particularly useful for targeting sensitive strains of Pseudomonas aeruginosa.
Protein Data Bank: Not Available
Source: DrugBank Online – Retrieved 2023-01-23 from