Scientific Name: Clobazam
Brand Name: Onfi, Sympazan
Company Owner: Not Available
Mechanism Of Action Clobazam binds at distinct binding sites associated with the chloride ionopore at the post-synaptic GABA receptor. These GABA receptors are in various locations in the CNS (limbic, reticular formation) and clobazam increases the duration of time for which the chloride ionopore is open. As a result, hyper polarization and stabilization of the membrane occur as the post-synaptic inhibitory effect of GABA is enhanced.
Description of the Drug: Clobazam is a benzodiazepine used as adjunct treatment in seizures associated with Lennox-Gastaut syndrome.
Protein Data Bank: Not Available
Source: DrugBank Online – Retrieved 2023-01-23 from