Scientific Name: Cidofovir
Brand Name: Vistide
Company Owner: Gilead sciences inc
Mechanism Of Action Cidofovir acts through the selective inhibition of viral DNA polymerase. Biochemical data support selective inhibition of CMV DNA polymerase by cidofovir diphosphate, the active intracellular metabolite of cidofovir. Cidofovir diphosphate inhibits herpesvirus polymerases at concentrations that are 8- to 600-fold lower than those needed to inhibit human cellular DNA polymerase alpha, beta, and gamma(1, 2, 3) . Incorporation of cidofovir into the growing viral DNA chain results in reductions in the rate of viral DNA synthesis.
Description of the Drug: Cidofovir is an antiviral agent used to treat Cytomegalovirus (CMV) retinitis in patients with AIDS.
Protein Data Bank:
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00369