Chlorpropamide

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Scientific Name: Chlorpropamide
Brand Name: Not Available
Company Owner: Barr laboratories inc, Clonmel healthcare ltd, Duramed pharmaceuticals inc sub barr laboratories inc, Halsey drug co inc, Ivax pharmaceuticals inc, Mylan pharmaceuticals inc, Par pharmaceutical inc, Pliva inc, Sandoz inc, Superpharm corp, Teva pharmaceuticals usa inc, Usl pharma inc, Watson laboratories inc, Pfizer laboratories div pfizer inc
Mechanism Of Action Sulfonylureas such as chlorpropamide bind to ATP-sensitive potassium channels on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin.
Description of the Drug: Chlorpropamide is a sulfonylurea used in the treatment of non insulin dependent diabetes mellitus.
Protein Data Bank: Not Available
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00672