Chlorpromazine

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Scientific Name: Chlorpromazine
Brand Name: Not Available
Company Owner: Glaxosmithkline, Actavis mid atlantic llc, Pharmaceutical assoc inc div beach products, Wockhardt eu operations (swiss) ag, Roxane laboratories inc, Sandoz inc, Abraxis pharmaceutical products, Baxter healthcare corp anesthesia and critical care, Marsam pharmaceuticals llc, Watson laboratories inc, Wyeth ayerst laboratories, Alpharma us pharmaceuticals division, Abbott laboratories pharmaceutical products div, Ivax pharmaceuticals inc sub teva pharmaceuticals usa, Kv pharmaceutical co, Lederle laboratories div american cyanamid co, Purepac pharmaceutical co, Private formulations inc, Usl pharma inc, Vangard laboratories inc div midway medical co, West ward pharmaceutical corp, Parke davis div warner lambert co
Mechanism Of Action Chlorpromazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 – different antipsychotic properties on productive and unproductive symptoms) , on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties) , on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain) , alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism – controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects) . Additionally, Chlorpromazine is a weak presynaptic inhibitor of Dopamine reuptake, which may lead to (mild) antidepressive and antiparkinsonian effects. This action could also account for psychomotor agitation and amplification of psychosis (very rarely noted in clinical use) .
Description of the Drug: Chlorpromazine is a phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children.
Protein Data Bank:
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00477