Chlorothiazide

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Scientific Name: Chlorothiazide
Brand Name: Diuril
Company Owner: Salix pharmaceuticals inc, Abc holding corp, Lederle laboratories div american cyanamid co, Mylan pharmaceuticals inc, Sandoz inc, Watson laboratories inc, West ward pharmaceutical corp, Lundbeck inc, App pharmaceuticals llc
Mechanism Of Action As a diuretic, chlorothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like chlorothiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of chlorothiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.
Description of the Drug: Chlorothiazide is a thiazide diuretic used to treat hypertension and edema in congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy.
Protein Data Bank: Not Available
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00880