Carglumic acid
Back to search| Scientific Name: | Carglumic acid |
| Brand Name: | Carbaglu |
| Company Owner: | Not Available |
| Mechanism Of Action | Carglumic acid is a synthetic structural analogue of N-acetylglutamate (NAG) , which is an essential allosteric activator of the liver enzyme carbamoyl phosphate synthetase 1 (CPS1) . CPS1 is found in the mitochondria and is the first enzyme of the urea cycle, which converts ammonia into urea. Carglumic acid acts as a replacement for NAG in NAGS deficiency patients by activating CPS1 but it does not help to regulate the urea cycle. |
| Description of the Drug: | Carglumic acid is an analog of N-acetylglutamate (NAG) used for the treatment of acute and chronic hyperammonemia in patients with N-acetylglutamate synthase (NAGS) deficiency. |
| Protein Data Bank: | Not Available |
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB06775
