Calcipotriol

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Scientific Name: Calcipotriol
Brand Name: Calcitrene, Dovobet, Dovonex, Enstilar, Sorilux, Taclonex, Wynzora
Company Owner: Not Available
Mechanism Of Action The precise mechanism of calcipotriol in remitting psoriasis is not well-understood, however, it has been shown to have comparable affinity with calcitriol for the Vitamin D receptor while being less than 1% the activity in regulating calcium metabolism. The Vitamin D receptor (VDR) belongs to the steroid/thyroid receptor superfamily, and is found on the cells of many different tissues including the thyroid, bone, kindney, and T cells of the immune system. T cells are known to play a role in psoriasis and are believed to undergo modulation of gene expression with binding of calcipotriol to the VDR. This modulation is thought to affect gene products related to cell differentiation and proliferation.
Description of the Drug: Calcipotriol is a topical synthetic vitamin D2 derivative used in the treatment of plaque psoriasis.
Protein Data Bank:
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB02300