Bumetanide

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Scientific Name: Bumetanide
Brand Name: Bumex, Burinex
Company Owner: Baxter healthcare corp anesthesia and critical care, Bedford laboratories div ben venue laboratories inc, Hospira inc, Teva parenteral medicines inc, Validus pharmaceuticals inc, Ivax pharmaceuticals inc sub teva pharmaceuticals usa, Sandoz inc
Mechanism Of Action Bumetanide interferes with renal cAMP and/or inhibits the sodium-potassium ATPase pump. Bumetanide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle, altering electrolyte transfer in the proximal tubule. This results in excretion of sodium, chloride, and water and, hence, diuresis.
Description of the Drug: Bumetanide is a sulfamyl diuretic used to treat edema in congestive heart failure, hepatic and renal disease, and nephrotic syndrome.
Protein Data Bank:
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00887