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Scientific Name: Brimonidine
Brand Name: Alphagan, Combigan, Lumify, Mirvaso, Onreltea, Qoliana, Simbrinza
Company Owner: Allergan inc, Allergan, Akorn inc, Alcon inc, Alcon research ltd, Bausch and lomb pharmaceuticals inc, Sandoz canada inc, Teva parenteral medicines inc, Allergan, Inc
Mechanism Of Action In the eye, alpha-1 adrenoceptors play a role in vasoconstriction, mydriasis, eyelid retraction, and elevation of intraocular pressure (IOP) whereas alpha-2 adrenoceptors are responsible for IOP reduction via a complex Gi-coupled signaling cascade pathway. Activation of alpha-2 receptors leads to inhibition of adenylyl cyclase and reduction of cyclic AMP levels. As a result, there is a decrease in norpinephrine (NE) release at the synaptic junction, NE-induced stimulation of beta-2 adrenoceptors, and production of aqueous humor by the ciliary epithelium.
Description of the Drug: Brimonidine is an alpha-2 adrenergic agonist used to treat glaucoma and ocular hypertension, as well as facial erythema in rosacea.
Protein Data Bank:
Source: DrugBank Online – Retrieved 2023-01-23 from