Balsalazide
Back to search| Scientific Name: | Balsalazide |
| Brand Name: | Colazal |
| Company Owner: | Apotex inc etobicoke site, Mylan pharmaceuticals inc, Roxane laboratories inc, Salix pharmaceuticals inc |
| Mechanism Of Action | The mechanism of action of 5-aminosalicylic acid is unknown, but appears exert its anti-inflammatory effects locally (in the GI tract) rather than systemically. Mucosal production of arachidonic acid metabolites, both through the cyclooxygenase pathways (catalyzes the formation of prostaglandin precursors from arachidonic acid) , and through the lipoxygenase pathways (catalyzes the formation of leukotrienes and hydroxyeicosatetraenoic acids from arachidonic acid and its metabolites) , is increased in patients with chronic inflammatory bowel disease. Therefore, it is possible that 5-aminosalicylic acid diminishes inflammation by blocking production of arachidonic acid metabolites in the colon through both the inhibition of cyclooxygenase and lipoxygenase. |
| Description of the Drug: | Balsalazide is an aminosalicylate used to treat ulcerative colitis. |
| Protein Data Bank: | Not Available |
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB01014
