Scientific Name: Aztreonam
Brand Name: Azactam, Cayston
Company Owner: Gilead sciences inc, Bristol myers squibb, Bristol myers squibb co, App pharmaceuticals llc
Mechanism Of Action The bactericidal action of aztreonam results from the inhibition of bacterial cell wall synthesis due to a high affinity of aztreonam for penicillin binding protein 3 (PBP3) . By binding to PBP3, aztreonam inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins. It is possible that aztreonam interferes with an autolysin inhibitor.
Description of the Drug: Aztreonam is a beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria.
Protein Data Bank:
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00355