Avacopan
Back to search| Scientific Name: | Avacopan |
| Brand Name: | Tavneos |
| Company Owner: | Not Available |
| Mechanism Of Action | Anti-neutrophil cytoplasmic (auto) antibody (ANCA) -associated vasculitis (AAV) is considered a “pauci-immune” form of systemic small-vessel vasculitis accompanied by the presence of ANCAs in the serum. The full spectrum of AAV includes granulomatosis with polyangiitis (GPA) , microscopic polyangiitis (MPA) , eosinophilic granulomatosis with polyangiitis (EGPA) , and drug-induced AAV. AAV may be associated with necrotizing and crescentic glomerulonephritis (NCGN) . Of the various known ANCAs, the major antigens are myeloperoxidase (MPO) and proteinase 3 (PR3/myeloblastin) . |
| Description of the Drug: | Avacopan is an orally bioavailable complement 5a receptor (C5aR) antagonist for the treatment of severe anti-neutrophil cytoplasmic (auto) antibody (ANCA) -associated vasculitis. |
| Protein Data Bank: |
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB15011
