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Scientific Name: Anagrelide
Brand Name: Agrylin, Xagrid
Company Owner: Shire development inc, Alphapharm pty ltd, Barr laboratories inc, Impax laboratories inc, Ivax pharmaceuticals inc sub teva pharmaceuticals usa, Mylan laboratories inc, Roxane laboratories inc, Sandoz inc, Watson laboratories
Mechanism Of Action The exact mechanism by which anagrelide lowers platelet count is unclear. Evidence from human trials suggests a dose-related suppression of megakaryocyte maturation, the cells responsible for platelet production – blood drawn from patients receiving anagrelide showed a disruption to the post-mitotic phase of megakaryocyte development and a subsequent reduction in their size and ploidy.
Description of the Drug: Anagrelide is a platelet-reducing agent used to treat thrombocythemia, and its related complications, secondary to myeloproliferative neoplasms.
Protein Data Bank:
Source: DrugBank Online – Retrieved 2023-01-23 from