Amphotericin B
Back to search| Scientific Name: | Amphotericin B |
| Brand Name: | Abelcet, Ambisome, Amphotec, Fungizone |
| Company Owner: | Apothecon inc div bristol myers squibb, Sigma tau pharmaceuticals inc, Three rivers pharmaceuticals llc, Astellas pharma us inc, Abbott laboratories, Abraxis pharmaceutical products, Teva parenteral medicines inc, X gen pharmaceuticals inc, Bristol myers squibb co |
| Mechanism Of Action | Amphotericin B is fungistatic or fungicidal depending on the concentration obtained in body fluids and the susceptibility of the fungus. The drug acts by binding to sterols (ergosterol) in the cell membrane of susceptible fungi. This creates a transmembrane channel, and the resultant change in membrane permeability allowing leakage of intracellular components. Ergosterol, the principal sterol in the fungal cytoplasmic membrane, is the target site of action of amphotericin B and the azoles. Amphotericin B, a polyene, binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. |
| Description of the Drug: | Amphotericin B is an antifungal used to treat fungal infections in neutropenic patients, cryptococcal meningitis in HIV infection, fungal infections, and leishmaniasis. |
| Protein Data Bank: | Not Available |
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00681
