Amifampridine
Back to search| Scientific Name: | Amifampridine |
| Brand Name: | Firdapse, Ruzurgi |
| Company Owner: | Not Available |
| Mechanism Of Action | Amifampridine is a symptomatic treatment that increases acetylcholine concentrations at the neuromuscular junction. It selectively blocks presynaptic fast voltage-gated potassium channels, thereby prolonging cell membrane depolarization and action potential, and augmenting calcium transport into the nerve endings. Increased intracellular calcium enhances the exocytosis of acetylcholine-containing vesicles and enhances impulse transmission at central, autonomic, and neuromuscular synapses |
| Description of the Drug: | Amifampridine is a voltage gated potassium channel blocker used to treat Lambert-Eaton myasthenic syndrome. |
| Protein Data Bank: |
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB11640
