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Scientific Name: Amantadine
Brand Name: Gocovri, Osmolex
Company Owner: Actavis totowa llc, Banner pharmacaps inc, Sandoz inc, Usl pharma inc, Watson laboratories inc, Solvay pharmaceuticals, Endo pharmaceuticals inc, Actavis mid atlantic llc, Carolina medical products co, Hi tech pharmacal co inc, Mikart inc, Pharmaceutical assoc inc div beach products, Silarx pharmaceuticals inc, Teva pharmaceuticals usa, Vintage pharmaceuticals llc, Wockhardt eu operations (swiss) ag
Mechanism Of Action The mechanism of its antiparkinsonic effect is not fully understood, but it appears to be releasing dopamine from the nerve endings of the brain cells, together with stimulation of norepinephrine response. It also has NMDA receptor antagonistic effects. The antiviral mechanism seems to be unrelated. The drug interferes with a viral protein, M2 (an ion channel) , which is needed for the viral particle to become “uncoated” once it is taken inside the cell by endocytosis.
Description of the Drug: Amantadine is a medication used to treat dyskinesia in Parkinson’s patients receiving levodopa, as well as extrapyramidal side effects of medications.
Protein Data Bank: Not Available
Source: DrugBank Online – Retrieved 2023-01-23 from