Alitretinoin

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Scientific Name: Alitretinoin
Brand Name: Panretin, Toctino
Company Owner: Eisai inc
Mechanism Of Action Alitretinoin binds to and activates all known intracellular retinoid receptor subtypes (RARa, RARb, RARg, RXRa, RXRb and RXRg) . Once activated these receptors function as transcription factors that regulate the expression of genes that control the process of cellular differentiation and proliferation in both normal and neoplastic cells.
Description of the Drug: Alitretinoin is a vitamin A derivative used to treat Kaposi’s sarcoma and used off label to treat chronic hand eczema and psoriasis.
Protein Data Bank:
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00523