| Scientific Name: |
Alitretinoin |
| Brand Name: |
Panretin, Toctino |
| Company Owner: |
Eisai inc |
| Mechanism Of Action |
Alitretinoin binds to and activates all known intracellular retinoid receptor subtypes (RARa, RARb, RARg, RXRa, RXRb and RXRg) . Once activated these receptors function as transcription factors that regulate the expression of genes that control the process of cellular differentiation and proliferation in both normal and neoplastic cells. |
| Description of the Drug: |
Alitretinoin is a vitamin A derivative used to treat Kaposi’s sarcoma and used off label to treat chronic hand eczema and psoriasis. |
| Protein Data Bank: |
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