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Scientific Name: Afamelanotide
Brand Name: Scenesse
Company Owner: Not Available
Mechanism Of Action Patients with erythropoietic porphyria (EPP) have a deficiency of ferrochelatase (FECH) , an enzyme involved in the final step of heme biosynthesis. FECH is required to insert iron into protoporphyrin IX (PPIX) to generate heme, and a deficiency in FECH results in accumulation of PPIX (particularly in the liver and superficial skin vasculature) . PPIX molecules are photodynamic – exposure to UV radiation causes these molecules to form reactive oxygen species that lead to subsequent tissue damage.
Description of the Drug: Afamelanotide is an injectable subcutaneous implant used to mitigate phototoxicity secondary to erythropoietic protoporphyria (EPP) .
Protein Data Bank: Not Available
Source: DrugBank Online – Retrieved 2023-01-23 from