Scientific Name: Adapalene
Brand Name: Differin, Epiduo, Tactupump
Company Owner: Nycomed us inc, Galderma laboratories lp, Glenmark generics inc usa, Pliva hrvatska doo, Galderma research and development inc, Galderma Laboratories
Mechanism Of Action Adapalene is used for the treatment/maintenance of mild-to-severe acne (acne vulgaris) . Acne is a multifactorial condition, and evidence exists to support multiple mechanisms of action for adapalene. Adapalene binds to retinoic acid receptor (RAR) -beta and RAR-gamma; this complex subsequently binds to one of three retinoid X receptors (RXRs) , which as a complex is capable of binding DNA to modulate transcriptional activity.
Description of the Drug: Adapalene is a third-generation topical retinoid with anti-comedogenic, comedolytic, and anti-inflammatory properties used to treat acne vulgaris in adolescents and adults.
Protein Data Bank: Not Available
Source: DrugBank Online – Retrieved 2023-01-23 from